At HOPO Therapeutics, we are working towards a future free from the damage caused by lead poisoning. About 1 in 3 children - up to 800 million globally - have dangerously high blood lead levels. Across the world, contaminated drinking water, lead-based paint, and many other sources of exposure silently poison children in their homes. Women who have been exposed to lead also pass the toxin on during pregnancy, causing irreversible damage to children’s brains and bodies that persists throughout their lives. This “Silent Epidemic” is an urgent and transgenerational issue in women’s and children’s health, and a devastating example of health inequity.
HOPO Therapeutics develops best-in-class pharmaceuticals for the treatment of heavy metal contamination. We are developing formulations of our flagship active pharmaceutical ingredient, 3,4,3-LI(1,2-HOPO), for the treatment of lead poisoning, as well as exposure to other toxic environmental contaminants like cadmium, gadolinium deposited in the body after exposure to MRI contrast agents, and protection from radioactive elements like plutonium and americium in a nuclear disaster.
Our class-leading heavy metal chelating agents have been optimized for maximum efficacy, safety, and oral availability, and are effective for both the treatment and prevention of heavy metal deposition. More about our science.
HOPO-001, an oral formulation of our lead compound, has been granted Investigational New Drug status by the FDA, and we anticipate a first-in-human Phase I clinical trial to begin in 2022.
Co-founder and CEO Julian Rees, Ph.D. discusses a shift in HOPO’s focus area in last week’s newsletter READ
The UC Berkeley-based startup incubator / accelerator provides a vast network of resources, contacts, and guidance to help us achieve our mission
Rebecca Abergel, Ph.D. and Julian Rees, Ph.D. have received a Bakar Fellowship from UC Berkeley to advance the commercial development of our heavy metal chelator 3,4,3,-LI(1,2-HOPO)
Huge congratulations to co-founder Rebecca Abergel, Ph.D. on her promotion to Associate Professor with tenure!
HOPO Therapeutics, Inc.
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