Publications
Proceedings of the National Academy of Sciences • Apr 2021
Genome-wide toxicogenomic study of the lanthanides sheds light on the selective toxicity mechanisms associated with critical materials
Roger M. Pallares, David Faulkner, Dahlia D. An, Solene Hebert, Alex Loguinov, Michael Proctor, Jonathan A. Villalobos, Kathleen A. Bjornstad, Chris J. Rosen, Christopher Vulpe, Rebecca J. Abergel
Nature • Feb 2021
Structural and spectroscopic characterization of an einsteinium complex
Korey P. Carter, Katherine M. Shield, Kurt F. Smith, Zachary R. Jones, Jennifer N. Wacker, Leticia Arnedo-Sanchez, Tracy M. Mattox, Liane M. Moreau, Karah E. Knope, Stosh A. Kozimor, Corwin H. Booth, Rebecca J. Abergel
Scientific Reports • Mar 2018
Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents
Julian A. Rees, Gauthier J.-P. Deblonde, Dahlia D. An, Camille Ansoborlo, Stacey S. Gauny, Rebecca J. Abergel
New Journal of Chemistry • Feb 2018
Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO)
Gauthier J.P. Deblonde, Trevor D. Lohrey, Dahlia D. An, Rebecca J. Abergel
Chemico-Biological Interactions • Apr 2017
From early prophylaxis to delayed treatment: Establishing the plutonium decorporation activity window of hydroxypyridinonate chelating agents.
Dahlia D. An, Birgitta Kullgren, Erin E. Jarvis, Rebecca J. Abergel
Drug Development Research • May 2015
Biodistribution of the Multidentate Hydroxypyridinonate Ligand [ 14 C]-3,4,3-LI(1,2-HOPO), a Potent Actinide Decorporation Agent
Taylor A. Choi, Aaron N. Endsley, Deborah I. Bunin, Christophe Colas, Dahlia D. An, Joel A. Morales-Rivera, Jonathan A. Villalobos, Walter M. Shinn, Jack E. Dabbs, Polly Y. Chang, Rebecca J. Abergel
Inorganic Chemistry • Apr 2015
Hydroxypyridinonate Complex Stability of Group (IV) Metals and Tetravalent f-Block Elements: The Key to the Next Generation of Chelating Agents for Radiopharmaceuticals
Manuel Sturzbecher-Hoehne, Taylor A. Choi, Rebecca J. Abergel
International Journal of Radiation Biology • Nov 2014
238 Pu elimination profiles after delayed treatment with 3,4,3LI(1,2HOPO) in female and male Swiss-Webster mice
Dahlia D An, Jonathan A Villalobos, Joel A Morales-Rivera, Chris J Rosen, Kathleen A. Bjornstad, Stacey S Gauny, Taylor A Choi, Manuel Sturzbecher-Hoehne, Rebecca J Abergel
Journal of Chromatography & Separation Techniques • Dec 2013
Analytical Methods for the Bioavailability Evaluation of Hydroxypyridinonate Actinide Decorporation Agents in Pre-Clinical Pharmacokinetic Studies
Polly Y. Chang, Deborah I. Bunin, Jason Gow, Robert Swezey, Walter Shinn, David K. Shuh, Rebecca J. Abergel
Inorganic Chemistry • Aug 2013
Solution Thermodynamic Stability of Complexes Formed with the Octadentate Hydroxypyridinonate Ligand 3,4,3-LI(1,2-HOPO): A Critical Feature for Efficient Chelation of Lanthanide(IV) and Actinide(IV) Ions
Gauthier J-P. Deblonde, Manuel Sturzbecher-Hoehne, Rebecca J Abergel
Radiation Research • Jan 2013
Dose-dependent efficacy and safety toxicology of hydroxypyridinonate actinide decorporation agents in rodents: towards a safe and effective human dosing regimen.
Deborah I Bunin, Polly Y Chang, Rupa S Doppalapudi, Edward S Riccio, Dahlia An, Erin E Jarvis, Birgitta Kullgren, Rebecca J Abergel
Dalton Transactions • Jan 2011
3,4,3-LI(1,2-HOPO): In vitro formation of highly stable lanthanide complexes translates into efficacious in vivo europium decorporation
Manuel Sturzbecher-Hoehne, Clara Ng Pak Leung, Anthony D’Aléo, Birgitta Kullgren, Anne-Laure Prigent, David K Shuh, Kenneth N Raymond, Rebecca J Abergel
Health Physics • Sep 2010
Biomimetic Actinide Chelators: An Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO)
Rebecca J. Abergel, Patricia W. Durbin, Birgitta Kullgren, Shirley N. Ebbe, Jide Xu, Polly Y. Chang, Deborah I. Bunin, Eleanor A. Blakely, Kathleen A. Bjornstad, Chris J. Rosen, David K. Shuh, Kenneth N. Raymond
International Journal of Radiation Biology • Feb 2000
Multidentate hydroxypyridinonate ligands for Pu(IV) chelation in vivo: comparative efficacy and toxicity in mouse of ligands containing 1,2-HOPO or Me-3,2-HOPO.
P W Durbin, B Kullgren, J Xu, K N Raymond
Radiation Protection Dosimetry • May 1994
In Vivo Chelation of Am(III), Pu(IV), Np(V), and U(VI) in Mice by TREN-(Me-3,2-HOPO)
P.W. Durbin, B. Kullgren, J. Xu, K.N. Raymond
International Journal of Radiation Biology • Jan 1993
Comparative efficacies of 3,4,3-LIHOPO and DTPA for enhancing the excretion of plutonium and americium from the rat after simulated wound contamination as nitrates
G. N. Stradling, S. A. Gray, J. C. Moody, M. J. Pearce, I. Wilson, R. Burgada, T. Bailly, Y. Leroux, K. N. Raymond, P. W. Durbin
International Journal of Radiation Biology • Jan 1993
Early chelation therapy for injected pu-238 and am-241 in the rat: Comparison of 3,4,3-LIHOPO, DFO-HOPO, DTPA-DX, DTPA and DFOA
V. Volf, R. Burgada, K. N. Raymond, P. W. Durbin
